Table 2.

Comparison between clinical and hormonal features of boys with and without MKRN3 mutations

	MKRN3 mutations (n = 8)	Idiopathic CPP (n = 11)	p value
Age at pubertal onset, years	8.2 (5.9 – 8.6)	7.0 (0.9 – 8.0)	0.033
Age at first evaluation, years	8.7 (8.1 – 9.8)	8.7 (1.4 – 10.4)	0.817
BMI, Z-score	1.2 (0.14 – 2.2)	1.7 (0.2 – 4.0)	0.314
Bone age advancement, years	1.7 (0 – 2.7)	1.7 (0 – 7.9)	0.383
Basal LH, IU/l	1.5 (0.7 – 4.1)	1.2 (0.7 – 6.7)	1.000
LH after GnRH, IU/l	10.9 (6.7 – 20)	18 (8.4 – 33.4)	0.268
Basal FSH, IU/l	1.9 (0.8 – 4.4)	2.5 (0.7 – 5.9)	0.649
Testosterone, ng/dl	200 (67 – 548)	75.7 (19 – 297)	0.103

Data are presented as median (range). The boy with a MKRN3 mutation and testosterone level <10 ng/dl (patient 17, table 1) was excluded from the testosterone level analysis.