Fig. 1.

The ‘Pathogen Box’ from the Medicines for Malaria Venture (MMV) (Panel A) contains 400 diverse drug-like molecules with confirmed activity against one or more key pathogens that cause some of the most socioeconomically important diseases worldwide, including malaria, toxoplasmosis, cryptosporidiosis, trypanosomiasis, leishmaniasis, hookworm disease, trichuriasis, schistosomiasis; numbers of chemicals active against different pathogen/pathogen groups are indicated in parentheses. The graphs (Panels B to D) show the activity of tolfenpyrad on the motility of exsheathed third-stage (xL3) and fourth-stage (L4) larvae of Haemonchus contortus (after 24 h, 48 h and 72 h of exposure) and on the development of the L4 stage (after 7 days of exposure), respectively.