Figure 1.

Schematic illustration of RNAi-AuNPs with various geometries constructed by programmed self-assembly formation between complementary base fairing between antisense and sense-RNA strands. RNA conjugated AuNP with n-designated numbers of RNA strands were produced by (a) thiol-ligand chemistry as (b) highly sophisticated building blocks to assemble (c) versatile RNAi-AuNP hybrid nanoconstructs. (d) Schematic illustration of a combinational strategy of anti-angiogenesis mechanisms and photothermal ablation to maximize anti-tumoral therapeutic efficacy. Anti-angiogenesis therapy with anti-VEGF siRNA to reduce tumor growth was performed on early tumor progress and photothermal therapy was sequentially followed to eradicate cancer completely at later stages of tumor development.