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Macroscopic images of inflamed joints from CIA mice treated with DS-g-MTX, Dex-g-MTX, free MTX, or NS as a control after 3 days of last injection (A). The macroscopic evidences of arthritis were assessed by arthritic sores in the process of treatment (B) and paw thickness after all treatments (C). Data were presented as mean ± SD (n = 6; **P < 0.01, ***P < 0.001). Scale bars: 5.0 mm.
