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Comparison of Cy5.5-HA10K and Cy5.5-PEG10K. (A) Representative images of Cy5.5-HA10K and Cy5.5-PEG10K at 30, 60 and 120 min after hock injection. Compared with Cy5.5-HA10K, Cy5.5-PEG10K showed less retention in popliteal LNs and faster migration into sciatic LNs. (B) Sciatic to popliteal ratio (SPR) at 30, 60, and 120 min after imaging agent administration. SPR of Cy5.5-HA10K is significantly lower than that of Cy5.5-PEG10K at all the time points (*, P< 0.05; **, P< 0.01).
