Figure 1.

A. Scheme 1 Synthesis of fumagillin (fumagillol) PAz-PC prodrug. B. Scheme 2 Synthesis of docetaxel prodrug. C. Structure α_vβ₃-peptidomimetic-PEG₂₀₀₀-PE. D. Example of dynamic light scattering micelle particle size distribution (α_vβ₃-Dxtl-PD). E. Averaged pharmacokinetic profile of α_vβ₃-micelles containing a Gd³⁺-lipid marker in the surfactant commixture. The two compartment model Gd³⁺ concentration (C) = A e^-αt + B e^-βt revealed an alpha distribution half-life of 6.9 min and a beta elimination half-life of 154.6 min.