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. 2017 Jan 1;7(2):413–424. doi: 10.7150/thno.15712

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Infiltration of mannose receptor-positive macrophages in myocarditis. (A) Inflammatory cells infiltrated the myocardium significantly in human myocarditis sample (left panel) as compared to normal human myocardium in heart transplantation recipients (right panel). H&E staining. (B) Adjacent section of samples in Figure 2A identified a significant proportion of the inflammatory cells to be positive for mannose receptor (brown color) in human myocarditis (left panel) as compared to normal human myocardium (right panel). Representative mannose receptor immunostaining images. n=3~4 per group. (C) Inflammatory cells significantly infiltrated the myocardium in the rat myocarditis sample (left panel) as compared to minimal in the normal rat myocardium (right panel). Representative ED-1 immunostaining images. (D) RITC-MSA binds to mannose receptor-positive cells in rat myocarditis, which in turn are ED-1 positive. Red, MSA; green, mannose receptor (MR); white, ED-1; blue, DAPI.