Figure 8.
Utility of 68Ga-NOTA-MSA PET for early detection of myocardial inflammation in myocarditis before structural changes in the myocardium. (A) Representative 2-dimensional echocardiography images of the left ventricular (LV) short-axis view at baseline, week 1, 2 and 3 after initiation of immunization. There was no difference in the LV wall thickness during this period. (B) Representative 68Ga-NOTA-MSA PET images of the same rat in Figure 8A at baseline, week 1, 2 and 3 post-immunization. (C) Quantification of the 68Ga-NOTA-MSA on PET and LV wall thickness on echocardiography. Significant rise of the 68Ga-NOTA-MSA uptake is seen at week 2 on PET whereas the LV wall thickens at week 3 on echocardiography. The median value of each groups are shown as horizontal lines. SUV(R), standardized uptake value (ratio).