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Disorganization of the cuticular plate components. A–A″, In 2-month-old WT IHCs, F-actin (red, A) and spectrin (green, A′) are homogeneously distributed in the whole cuticular plate, except for the kinocilium imprint. A″, Merge of both labels. B–C″, In 2-month-old Tg 924 (B–B″) and Tg 771 (C–C″) mice, actin filaments and spectrin are concentrated toward the periphery of the IHC apical part, leaving an empty space at the cuticular plate center. Scale bars: 5 µm.
