Table 3.

Serum IL-6 and CRP tertiles at age 9 years and the odds of hypomania aged 22 years

				Hypomania symptoms: OR (95% CI) [p]
	Tertile	n	Hypomania, n (%)	Unadjusted	Model 1a	Model 2b	Model 3c
nd				1717	1699	1201	7809
IL-6
	Bottom	573	30 (5.24)	1	1	1	1
	Middle	551	39 (7.08)	1.38 (0.84–2.25) [0.202]	1.51 (0.91–2.48) [0.104]	1.59 (0.91–2.79) [0.106]	1.53 (0.98–2.42) [0.064]
	Top	593	47 (7.93)	1.55 (0.97–2.50) [0.069]	1.78 (1.09–2.89) [0.020]	1.87 (1.07–3.27) [0.028]	1.77 (1.10–2.85) [<0.001]
	Linear trend	1717	116 (6.76)	1.24 (0.98–1.56) [0.069]	1.32 (1.04–1.67) [0.021]	1.36 (1.03–1.78) [0.027]	1.31 (1.04–1.65) [0.022]
CRP
	Bottom	622	52 (8.36)	1	1	1	1
	Middle	532	34 (6.39)	0.75 (0.48–1.17) [0.207]	0.83 (0.53–1.31) [0.428]	0.87 (0.52–1.48) [0.614]	0.84 (0.52–1.34) [0.480]
	Top	567	30 (5.29)	0.61 (0.38–0.97) [0.038]	0.69 (0.43–1.11) [0.125]	0.71 (0.40–1.28) [0.232]	1.04 (0.67–1.62) [0.872]
	Linear trend	1721	116 (6.74)	0.78 (0.62–0.98) [0.033]	0.83 (0.65–1.05) [0.128]	0.85 (0.64–1.13) [0.266]	1.02 (0.81–1.29) [0.877]

IL-6, Interleukin-6; CRP, C-reactive protein; OR, odds ratio; CI, confidence interval; HCL-32, Hypomania Checklist; BMI, body mass index.

^aComplete case analysis adjusted for age at time of HCL-32 completion, sex and ethnicity.

^bComplete case analysis adjusted for age at time of HCL-32 completion, sex, ethnicity, socio-economic status, psychological and behavioural problems, BMI and maternal postnatal depression.

^cValues imputed for all participants who answered the question about atopy aged 10 years (n = 7809) and adjusted for age at time of HCL-32 completion, sex, ethnicity, socio-economic status, psychological and behavioural problems, BMI and maternal postnatal depression.

^dNumber of participants in each model.