Table 3.

Skin permeation parameters and reduction ratio of AMP with or without hair follicle-plugged skin.

Skin Permeation Parameter at Different pH		Non-PA Plugging	PA Plugging	Ratio #
pH 3.0	Q10 (μmol/cm2)	2.40 × 10−2 ± 7.55 × 10−3	1.17 × 10−2 ± 4.41 × 10−3	0.49
	P (cm/s)	8.70 × 10−9 ± 2.38 × 10−9	4.73 × 10−9 ± 2.02 × 10−9	0.54
	tlag (h)	2.53 ± 0.50	2.56 ± 0.40	1.01
	DL−2 (h−1)	1.17 × 10−4 ± 2.32 × 10−5	1.19 × 10−4 ± 1.86 × 10−5	1.02
	KL (cm)	7.58 × 10−5 ± 2.00 × 10−5	3.99 × 10−5 ± 1.70 × 10−6	0.52
pH 7.4	Q10 (μmol/cm2)	3.78 × 10−2 ± 1.41 × 10−3	2.73 × 10−2 ± 2.11 × 10−3	0.72
	P (cm/s)	1.61 × 10−7 ± 8.10 × 10−9	1.43 × 10−7 ± 1.61 × 10−8	0.89
	tlag (h)	3.85 ± 0.14	4.18 ± 0.24	1.09
	DL−2 (h−1)	1.78 × 10−4 ± 6.34 × 10−6	1.94 × 10−4 ± 1.11 × 10−5	1.09
	KL (cm)	9.06 × 10−4 ± 5.05 × 10−5	7.51 × 10−4 ± 1.05 × 10−4	0.83

Ratio ^#: PA plugging/non-PA plugging.