Table 2.

Design of experiment (DoE) and results obtained by full factorial design.

			Factor 1	Factor 2	Factor 3	Resolution-1 (R1)	Resolution-2 (R2)
Std.	Run	Type	A: EtOH (%)	B: MeOH (%)	C: Temperature (°C)	S-isomer and LGP	LGP and MET
6	1	Factorial	660	360	30	2.9	2.3
4	2	Factorial	660	440	20	3.5	1.8
5	3	Factorial	540	360	30	3.0	2.2
11	4	Center	600	400	25	3.3	2.1
2	5	Factorial	660	360	20	3.2	2.1
9	6	Center	600	400	25	3.3	2.1
7	7	Factorial	540	440	30	3.4	1.8
8	8	Factorial	660	440	30	2.9	2.1
1	9	Factorial	540	360	20	3.7	1.8
3	10	Factorial	540	440	20	4.3	1.3
10	11	Center	600	400	25	3.6	2.0

Std.: standard order; LGP: linagliptin; MET: metformin.