Table 3.

Analysis of variance (ANOVA) for the selected factorial model, used for prediction and model plots obtained with Design Expert.

Response	Source	Sum of Squares	Degrees of Freedom	Mean Square	F Value	p-Value Prob > F	Model Status	R2	Adjusted R2	Predicted R2
S-isomer and LGP	Model	1.44	3	0.48	15.45	0.0018	Significant
	A-EtOH %	0.45	1	0.45	14.49	0.0067
	B-MeOH %	0.21	1	0.21	6.78	0.0352
	C-Temp. °C	0.78	1	0.78	25.08	0.0016
	Residual	0.22	7	0.031
	Lack of Fit	0.16	5	0.032	1.05	0.5527	Not Significant
	Pure Error	0.06	2	0.030				0.8688	0.8125	0.6259
LGP and MET HCl	Cor total	1.66	10
	Model	0.67	3	0.22	1.22	0.3700	Not Significant
	A-EtOH %	0.18	1	0.18	0.99	0.3537
	B-MeOH %	0.25	1	0.25	1.34	0.2846
	C-Temp. °C	0.25	1	0.25	1.34	0.2846
	Residual	1.28	7	0.18
	Lack of Fit	0.54	5	0.11	0.29	0.8852	Not Significant	0.8781	0.8477	0.7890
	Pure Error	0.74	2	0.37
	Cor total	1.95	10