Table 1.

Reported curcumin derivatives/analogs with P-gp modulatory effect.

Compounds	MDR Cancer Model	Inhibitors of P-gp Function	Inhibitors of P-gp Expression	References
Unsymmetrical curcumin mimics with various amide moieties	MDR cervical adenocarcinoma	X		[56]
Heterocyclic cyclohexanone monocarbonyl analogs of curcumin	Human embryonic kidney cells and canine kidney cells transfected with wild-type P-gp	X		[57]
Chloro and asymmetrical series of synthetic curcumin derivatives	MDR acute lymphoblastic leukemia	X		[58]
Diketone and cyclohexanone curcumin analogs	MDR chronic myeloid leukemia	X	X	[59]

MDR: multidrug resistant.