Table 1.
ACh-Induced Dilation in Mesenteric Arteries from Control and TBI Rats: Percent Dilation and LogEC50 Values
| Control | TBI | |||||
|---|---|---|---|---|---|---|
| Treatment | Vasodilation elicited at ACh 1 μM (%) | LogEC50 | n | Vasodilation elicited at ACh 1 μM (%) | LogEC50 | n |
| ACh | 100 ± 1 | −7.4 ± 0.01 | 5 | 59 ± 9* | −7.2 ± 0.4 | 7 |
| + l-NNA | 46 ± 8* | −6.7 ± 0.5 | 5 | 55 ± 4 | −6.6 ± 0.2 | 7 |
| + nor-NOHA | 73 ± 9 | −7 ± 0.3 | 5 | 98 ± 1* | −7 ± 0.06 | 6 |
| + l-arginine | 79 ± 6* | −7.3 ± 0.3 | 5 | 95 ± 2* | −7 ± 0.4 | 6 |
| + l-sepiapterin | 90 ± 7 | −7.3 ± 0.3 | 5 | 91 ± 3 | −6.8 ± 0.1 | 5 |
ACh, acetylcholine; EC, endothelial cell; l-NNA, Nω-nitro-l-arginine; nor-NOHA, Nω-hydroxy-nor-arginine.
ACh (1 μm), l-NNA (100 μm), nor-NOHA (20 μm), l-arginine (100 μm), l-sepiapterin (1 μm). Each value represents the mean ± SEM of n number of experiments. *p < 0.0125 versus the same group with Ach alone; Mann-Whitney test with Bonferroni correction.