FIG. 1.

Representative section of a 6 h cell-treated animal (3 weeks post-traumatic brain injury [TBI]) showing white matter (WM) reorganization and region of interest (ROI) creation. Cortex lesion exhibits hyperintensive area on T2 map (A), which corresponds to the hypointensive area on the fractional anisotropy (FA) map (B), indicative of structural disruption. The hyperintensities on the FA map are detected in the cortex regions near the lesion (red arrows in B). A similar pattern is present on the entropy map (red arrows in C). Bielshowsky's silver and Luxol fast blue (B+LFB) stain (D, scale bars = 500 μm) reveals that these pericontusional cortex regions contain oriented and extended bundles of axons, suggesting WM reorganization. Whereas T2 hyperintensities identify the lesion area (A), the 6 pixel wide ROIs immediately adjacent to the lesion encompass the lesion boundary regions with structural remodeling (E).