FIG. 2.

Sets of T2 (A–C, G–I, M–O) and fractional anisotropy (FA) (D–F, J–L, P–R) maps longitudinally illustrating the structural remodeling with and without cell intervention after traumatic brain injury (TBI). Cell administration executed either at 6 h or 1 week post-TBI enhances white matter (WM) reorganization, as shown by the hyperintensities developing along the lesion boundary (arrows in E, F and K, L). A stronger therapeutic effect, indicated by the presence of wider and denser hyperintensive areas in the boundary regions on FA map, is found in the 6 h cell-treated animal than in the 1 week cell-treated animal (compare E, F with K, L in the lesion boundary regions). This microstructural remodeling progression, however, is less evident for the saline-treated animals (compare Q, R with E, F and K, L in the lesion boundary regions).