Table 1.
Pathological Correlation of the DTI and MTR Metrics versus Histological Quantification
| IHC | Group | FA | MD | AD | RD | MTR |
|---|---|---|---|---|---|---|
| SMI31 | Normal | 0.73 | 0.35 | 0.71 | −0.43 | 0.23 |
| MVM | 0.33 | 0.01 | 0.03 | −0.22 | −0.02 | |
| MBP | Normal | −0.26 | −0.11 | −0.11 | 0.09 | 0.30 |
| MVM | −0.12 | 0.39 | 0.53 | 0.34 | −0.55 | |
| DAPI | Normal | −0.52 | −0.47 | −0.65 | 0.49 | −0.33 |
| MVM | −0.02 | −0.54 | −0.75 | −0.36 | 0.67 | |
| Iba1 | Normal | −0.57 | −0.39 | −0.54 | 0.65 | −0.39 |
| MVM | −0.21 | −0.48 | −0.72 | −0.22 | 0.68 | |
| GFAP | Normal | −0.35 | −0.07 | −0.28 | −0.06 | 0.56 |
| MVM | 0.07 | −0.76 | −0.78 | −0.54 | 0.71 |
Bold characters mark the correlations with significant level <0.05.
DTI, diffusion tensor imaging; MTR, magnetization transfer ratio; IHC, immunohistochemistry; FA, fractional anisotropy; MD, mean diffusivity; AD, axial diffusivity; RD, radial diffusivity; MBP, myelin basic protein; DAPI, 4′,6-diamidino-2-phenylindole; Iba1, ionized calcium-binding adaptor molecule 1; GFAP, glial fibrillary acidic protein; MVM, mild ventriculomegaly.