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Schematic drawing of ER stress during VZV infection. During VZV infection, abundant viral glycoproteins (gp) are processed in the ER. Viral glycoproteins that are correctly folded traffic to the Golgi for further processing into complex-type glycoproteins (red arrow). During ER stress, viral glycoproteins that are soluble and incorrectly folded may exit by ERAD type I (green arrow). Viral glycoproteins that are misfolded and aggregated may exit by ERAD type II (blue arrow).
