Figure 2.

Mutations in the sodium channel protein that are associated with pyrethroid resistance in Aedes aegypti. Solid circles denote the mutations that have been functionally confirmed in Xenopus oocytes, half-solid circles indicate one of the substitutions has been confirmed in oocytes, and empty circles indicate the mutations that have not been confirmed or examined in oocytes. Amino acid positions of mutations are numbered based on the house fly sodium channel protein, Vssc1 (Genbank accession number: AAB47604). The numbers of the corresponding positions in AaNa_v (Genbank accession number: EU399181) are indicated in parenthesis.