Table 1.

Physiologic parameters of Ndcbe/Ncc dKO, Ncc knockout, and wild-type mice fed an NaCl-depleted diet for 6 days

Parameters	Ndcbe+/+;Ncc+/+	Ndcbe−/−;Ncc−/−	Ndcbe+/+;Ncc−/−
Blood
[K+], mmol/L	4.14±0.07	3.49±0.08a	3.61±0.09a
Hematocrit, %	42.4±0.5	44.5±0.4b	42.9±0.6
Creatinine, μM	11.5±0.9	10.6±1.2	9.7±0.8
Urine
Urine output, ml/24 h	1.16±0.10	1.56±0.23	1.56±0.18

Values are the means±SEMs. For K⁺, n=24, n=11, and n=19 for wild-type (Ndcbe^+/+;Ncc^+/+), Ndcbe^−/−;Ncc^−/−, and Ndcbe^+/+;Ncc^−/− mice, respectively. For hematocrit, n=23, n=11, and n=18 for wild-type (Ndcbe^+/+;Ncc^+/+), Ndcbe^−/−;Ncc^−/−, and Ndcbe^+/+;Ncc^−/− mice, respectively. For creatinine and urine output, n=18, n=11, and n=14 for wild-type (Ndcbe^+/+;Ncc^+/+), Ndcbe^−/−;Ncc^−/−, and Ndcbe^+/+;Ncc^−/− mice, respectively. Statistical significance between groups was assessed by ANOVA following Tukey multiple comparison tests when appropriated. [K⁺], potassium concentration.

^aP<0.001 versus wild-type mice.

^bP<0.05 versus wild-type mice.