Skip to main content
. 2016 Jun 13;28(1):197–208. doi: 10.1681/ASN.2015080852

Figure 2.

Figure 2.

Gallein attenuates renal fibrosis in 12-weeks TAC CHF mice. (A) Picrosirius red staining (×20) shows elevated renal interstitial and perivascular fibrosis (red color) in mice 12 weeks post-TAC, which is attenuated by gallein treatment. Protein expression of (B) the profibrotic marker α-SMA and (C) the fibrotic mediator ET-1 is elevated in the kidneys of CHF mice and attenuated by gallein treatment. Vehicle or gallein (10 mg/kg per day intraperitoneally) treatment was initiated 4 weeks post-TAC and continued until 12 weeks. Gallein was gradually titrated up to a maximal dose of 10 mg/kg per day and administered by intraperitoneal injection. G, gallein; V, vehicle. *P<0.05 (n=4–7 per group); **P<0.01 (n=4–7 per group); ***P<0.001 (n=4–7 per group).