Skip to main content
. 2016 Jun 13;28(1):197–208. doi: 10.1681/ASN.2015080852

Figure 3.

Figure 3.

GRK2, ETA, and ETB expression and membrane localization are elevated in the kidneys of TAC mice and attenuated by gallein. Protein expression (A) and membrane translocation (B) of GRK2 are elevated in kidneys of CHF mice and attenuated by gallein treatment. Expression of ET receptors (ETA (C, D) and ETB (E, F)) in the whole renal lysates as well as in the membrane fractions is elevated in CHF mice and attenuated by gallein treatment. Vehicle or gallein (10 mg/kg per day intraperitoneally) treatment was initiated 4 weeks post-TAC and continued until 12 weeks. Gallein was gradually titrated up to a maximal dose of 10 mg/kg per day and administered by intraperitoneal injection. G, gallein; V, vehicle. *P<0.05 (n=4–5 per group); **P<0.01 (n=4–5 per group); ***P<0.001 (n=4–5 per group); ****P<0.001 (n=4–5 per group).