Table 2.
High/Lowest activation z-score canonical pathways in both RP and normal papillary tissue, where gene expression differs from that in the control mucosa by at least twofold
| Ingenuity Canonical Pathways | P Value | Ratio | z-Score | Molecules in Pathway |
|---|---|---|---|---|
| acAMP-mediated signaling | 0.001 | 0.17 | 3.307 | AKAP12,HTR5A,PTGDR,MC3R,PTGER3,PDE3A,PDE4A,TAAR1,CHRM3,HRH3,OPRL1,PPP3R2,MC5R,AKAP14,PPP3R1,CNR2,PDE4D,PDE11A,DRD3,MC2R,HTR6,RGS2,CALML5,GRM8,OPRM1,SSTR3,GNAI1,DRD5,RAPGEF3,GRM4,MC4R,XCR1,P2RY14,AKAP4,CNGB1,LPAR1,PDE5A,ADCY10 |
| aCoagulation system | 0.002 | 0.29 | 2.530 | F11,BDKRB2,PLG,F9,PROS1,PROC,VWF,F7,TFPI,FGG |
| aGαs signaling | 0.01 | 0.18 | 2.500 | HTR6,RGS2,ADD2,HTR5A,MC3R,PTGDR,TAAR1,GNG13,DRD5,RAPGEF3,MC4R,CHRM3,GNB1,MC5R,GNB4,CNGB1,MRAS,ADCY10,GNG12,MC2R |
| aExtrinsic prothrombin activation pathway | 0.01 | 0.31 | 2.236 | PROS1,PROC,F7,TFPI,FGG |
| CREB signaling in neurons | 0.40 | 0.11 | 2.138 | POLR2F,CALML5,GRM8,GRID1,GRIA1,GRIK3,GNAI1,GNG13,GRM4,PRKCG,GNB1,GRM5,GNB4,PLCG2,MRAS,PLCB1,ADCY10,PLCL1,GNG12 |
| aGαi signaling | 0.02 | 0.17 | 1.807 | OPRM1,PTGER3,GRM8,SSTR3,GNAI1,GNG13,GRM4,HRH3,OPRL1,XCR1,GNB1,GNB4,P2RY14,LPAR1,CNR2,CAV1,MRAS,ADCY10,DRD3,GNG12 |
| Dopamine receptor signaling | 0.28 | 0.13 | 1.633 | MAOB,PPP1R14D,PPP2R5B,NCS1,DRD5,PPP1CB,SLC18A1,DRD3,ADCY10,CALY |
| Glutamate receptor signaling | 0.06 | 0.18 | 1.342 | GRM5,GNB1,CALML5,SLC17A7,GRM8,GRIA1,GRID1,GRIK3,DLG4,GRM4 |
| Phospholipase C signaling | 0.27 | 0.12 | 1.279 | MYL10,PPP1CB,GNG13,PPP3R2,GNB1,GNB4,PPP1R12B,PPP3R1,MRAS,PLCB1,ARHGEF2,GNG12,CALML5,ARHGEF4,MEF2A,PLA2G1B,RAPGEF3,ARHGEF17,CD79A,MYL1,PRKCG,MYL9,RHOQ,PLCG2,MEF2D,ADCY10,ARHGEF10,FNBP1 |
| Chemokine signaling | 0.19 | 0.14 | 1.265 | ROCK2,CCR3,CALML5,PPP1R12B,PLCG2,MRAS,GNAI1,PLCB1,PPP1CB,NOX1 |
| Synaptic long term depression | 0.29 | 0.12 | 1.213 | GRM8,GRID1,GRIA1,PPP2R5B,PLA2G1B,GNAI1,PPP1R17,GRM4,PRKCG,GRM5,PRKG1,PLCG2,PLB1,GUCY1A2,MRAS,PLCB1,PLCL1 |
| aCalcium signaling | 0.02 | 0.15 | 1.155 | CHRNA1,CALML5,TRPC1,GRIA1,MYH14,TRDN,MEF2A,TNNI3,CHRNB4,SLC8A2,TPM1,TPM2,ATP2A2,MYL1,TRPC7,ATP2B2,ATP2A1,MYL9,PPP3R2,CHRNG,ACTA2,ATP2B3,MEF2D,PPP3R1,TNNI1,SLC8A1,ATP2B4 |
| PPARα/RXRα activation | 0.48 | 0.11 | 1.147 | CYP2C18,ACVR1,ADIPOQ,CYP2C9,BMPR2,ABCA1,CYP2C19,GK,PLCG2,INS,MRAS,TGFB2,TGFB3,SMAD4,PLCB1,PLCL1,ADCY10,ACVR1C,MAP4K4 |
| Gα12/13 signaling | 0.05 | 0.15 | −1.414 | VAV2,F2RL2,MYL10,CDH4,MEF2A,MYL1,CDH11,ROCK2,MYL9,CDH9,CDH12,LPAR1,VAV3,MEF2D,MRAS,CDH17,CDH8,CDH13 |
CREB, cAMP responsive element binding protein; PPARα/RXRα, peroxisome proliferator activated receptor alpha/retinoid X receptor alpha.
a
P<0.05 indicates significant difference.