Table 1.

The 24-hour renal metabolism in TG animals receiving doxycycline for indicated durations

Group	Week 0	Week 1	Week 2	Week 4
Weight, g	18.34±0.96	20.28±0.95	19.13±0.75	19.87±0.49
UV, µl/24 h per g	68.66±8.11	52.80±4.98	65.57±8.12	59.44±6.50
CCr, ml/24 h per g	2.60±0.47	2.11±0.23	2.59±0.17	2.44±0.37
UOsm, Osm/kg water	1.544±0.128	1.663±0.092	1.755±0.117	1.576±0.077
UAl/UCr, µg/µg	0.109±0.035	0.131±0.034	0.167±0.089	1.078±0.574a

Values are expressed as mean ±SEM.

UV, urinary volume; C_Cr, creatinine clearance rate; U_Osm, urinary osmolality; U_Al/U_Cr, the ratio of urinary albumin to urinary creatinine.

^aP<0.01 versus week 0; n=14 mice for each time point.