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. 2016 Jun 27;28(1):218–229. doi: 10.1681/ASN.2015121376

Figure 3.

Figure 3.

Renal inflammation associated with AKI is modulated by Fer-1. (A) Fer-1 prevented the increase in kidney TNFα, MCP-1, and RANTES mRNA levels at 48 hours of AKI. Mean±SEM of seven animals per group. **P<0.002 versus control; #P<0.03 versus AKI alone; ##P<0.003 versus AKI alone. (B and C) Quantification of kidney Fn14 and Klotho mRNA levels. Fer-1 prevented (B) the increase in Fn14 and (C) the decrease in Klotho mRNA expression in AKI at 48 hours. Mean±SEM of seven animals per group. **P<0.003 versus control; #P<0.03 versus AKI alone; ##P<0.003 versus AKI alone. (D) Fer-1 prevented the increase in F4/80–positive interstitial macrophages in AKI kidneys. Mean±SEM of seven animals per group. Original magnification, ×200. Scale bars, 50 μm. **P<0.002 versus control; ##P<0.001 versus AKI alone.