Skip to main content
. 2016 Jun 27;28(1):218–229. doi: 10.1681/ASN.2015121376

Figure 9.

Figure 9.

RIPK3 deficiency prevented renal inflammation in FA-induced AKI. (A) Kidney IL-33 protein levels were not reduced in RIPK3-KO mice 48 hours after AKI induction. Mean±SEM of seven or eight animals per group. **P<0.004 versus control. (B) Interstitial inflammation was assessed by a peritubular inflammation score, which had a maximum value of three. Data are means±SEM of seven or eight mice per group. *P<0.04 versus control wild type (WT); #P<0.02 versus AKI WT. (C and D) Kidney Fn14 and MCP-1 mRNA levels are lower in RIPK3-KO than in WT mice. Mean of seven or eight animals per group. **P<0.01 versus control WT; #P<0.02 versus AKI WT. (E) RIPK3 deficiency prevented the increase in F4/80–positive interstitial macrophages in AKI kidneys. Quantification as mean±SEM of seven or eight mice per group. Original magnification, ×200. Scale bars, 50 μm. **P<0.001 versus control WT; ##P<0.001 versus AKI WT.