FIG 3.

The δ and ω factors of RNAP have distinct and contrasting influences on S. aureus gene expression. (Top) Genomic map of altered transcription in the rpoZ mutant strain. The outermost circle (gray) represents annotations for the S. aureus USA300 genome. Blue (upregulation) and red (downregulation) bars show genes with differential expression in the rpoZ mutant (a maximum change of ±7-fold is displayed). Labels represent either gene names or USA300 gene numbers. (Bottom right) Number of genes changed in expression upon rpoZ depletion at ≥2-fold (232) or ≥3-fold (63). (Bottom left) Comparison of RNA sequencing data sets for ΔrpoE (δ) and ΔrpoZ (ω) strains. Shown are the number of genes within each regulon and the overlap between the two data sets (only ∼10% was detected).