Table 5.

Proposed diagnostic criteria of kidney dysfunction in cirrhosis - adapted from reference (126)

Diagnosis	Definition
Acute kidney injury	Rise in serum creatinine of ≥ 50% from baseline or a rise of serum creatinine by ≥ 26.5 μmol/L (≥ 0.3 mg/dL) in <48 h HRS type 1 is a specific form of acute kidney injury
Chronic kidney disease	Glomerular filtration rate of <60 ml/min for >3 months calculated using MDRD6 formula HRS type 2 is a specific form of chronic kidney disease
Acute-on-chronic kidney disease	Rise in serum creatinine of ≥ 50% from baseline or a rise of serum creatinine by ≥ 26.5 μmol/L (≥ 0.3 mg/dL) in <48 h in a patient with cirrhosis whose glomerular filtration rate is <60 ml/min for >3 months calculated using MDRD6 formula

• Both the acute deterioration in renal function and the background chronic renal dysfunction can be functional or structural in nature.

• MDRD6=Modification of Diet in Renal Disease formula calculated using six variables of serum creatinine, age, gender, albumin, blood urea nitrogen and whether or not the patient is African-American