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OATP-mediated doxorubicin transport in vitro in HeLa cells. A panel of uptake transporters was assessed for doxorubicin (0.2 µM) transport activity at 10 minutes. Vector control (pEF6) was used as reference. Human OATP1A2, but not OATP1B1 and OATP1B3, was capable of transporting doxorubicin. Rat Oatp1a1 and Oatp1a4 also transport doxorubicin. Data were expressed as percentage of cellular uptake compared with vector control (mean ± S.E., n = 6). *P < 0.05; **P < 0.01; ***P < 0.001.
