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. 2017 Jan;91(1):14–24. doi: 10.1124/mol.116.105544

Fig. 7.

Fig. 7.

Doxorubicin disposition studies in wild-type and Slco1a/1b−/− mice. Mice were administered a single intravenous dose of doxorubicin (1 mg/kg, sp act 1.2 Ci/mmol). Slco1a/1b−/− mice have significantly higher doxorubicin plasma AUC than wild-type mice (A). Doxorubicin concentration in liver (B) and the liver-to-plasma ratio (C) were significantly lower in Slco1a/1b−/− mice compared with wild-type mice. Data were expressed as mean ± SD (n = 8 for WT mice; n = 6 for KO mice; 8–13 weeks of age). *P < 0.05; **P < 0.01; ***P < 0.001.