TABLE 1.

Identification of the minimum pharmacophore: biologic activities and molecular weights of VU0652925 analogs

Platelet activation was induced by 200 μM PAR4-AP, 100 nM γ-thrombin, or 20 μM PAR1-AP. Data are presented as the means of at least three independent experiments. Experiments were conducted at 10 μM antagonist for the percent maximum values.

Example	VU Number	PAR4-AP		γ-Thrombin		PAR1-AP	MW
		Max PAC-1	IC50 PAC-1	Max PAC-1	IC50 PAC-1	Max PAC-1
		%	pM	%	nM	%
1	VU0652925	0	43	0	229b	94	460.53
2	VU0661247	0	210	0	3.03	51.5	407.44
3	VU0661245	0	472	0	8.42	92.6	331.35
4	VU0807074	0.19	1.68a	21.1	16.2	105	301.32
5	VU0807081	0.27	176	0	7.18	102	301.32
6	VU0806526	0.20	1.69a	6.99	58.8	111	271.04

MW, molecular weight.

^aValues are given in nanomoles.

^bValues are given in picomoles.