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Glutathione depletion potentiates mitoxantrone-mediated TOP2 covalent complex formation and H2AX phosphorylation. NB4 cells were preincubated with SA, BSO, or both as described for Fig 4, followed by addition of 1 μM mitoxantrone for 1 hour. TOP2A TARDIS (A), TOP2B TARDIS (B), and γH2AX assays (C) were performed as described in Figs 1 and 3. *P < 0.05; **P < 0.01; ***P < 0.001.
