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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Nat Rev Mol Cell Biol. 2016 Oct 5;18(1):5–17. doi: 10.1038/nrm.2016.121

Figure 1. Reverse topology membrane scission.

Figure 1

a| “Normal” and “reverse” topology membrane scission: “Normal” scission such as occurs in clathrin and coated vesicle biogenesis, whereas “reverse” scission carried out by ESCRTs acts in vesicle budding away from the cytosol. Note that a fundamental difference arises from only the cytosolic membrane side being accessible for protein scaffolding and scission machinery. b| Functions of the ESCRT pathway (right) compared with “normal” scission functions (left). Clathrin, COPI, and COPII are vesicle coats, while AP-1 and AP-2 are adaptor complexes that connect clathrin to membranes and vesicular cargo.