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. Author manuscript; available in PMC: 2016 Dec 29.
Published in final edited form as: Neurocrit Care. 2014 Apr;20(2):193–201. doi: 10.1007/s12028-013-9917-z

Figure 2. Vasogenic edema on T2 FLAIR is attenuated by glyburide treatment in human stroke.

Figure 2

A) Representative examples of DWI (lefthand panels) and FLAIR sequences (righthand panels) from a control subject (top panels) and a glyburide-treated subject (bottom panels). MRI scans were obtained at Day 2 from the onset of stroke. B) Quantitative analysis of the FLAIR ratio in control and GAMES subjects shows a reduced FLAIR ratio with glyburide treatment. Dots represent median, whiskers are the interquartile range. ***, p<0.005 by repeated measures MANOVA. C) Segmentation of the stroke lesions demonstrate an equivalent effect of glyburide on both gray and white matter regions. Box plots show the median and interquartile range, and whiskers show the range. **, p<0.01. D) The pharmacokinetic concentration of glyburide correlates with FLAIR ratio intensity in the GAMES-Pilot subjects. Glyburide concentration was dichotomized at 25 ng/mL (see text). The FLAIR ratio values were higher at the low glyburide concentration group compared to the high concentration group. Box plots show the median and interquartile range, and whiskers show the range. *, p=0.01.