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Metabolomic response to chronic high or low glucose altered by ISX. (A) Relative abundances of metabolites extracted from three independent passages of MIN6 cells. Coloring reflects a log2 scale. (B–E) Volcano plots display the log10 (adjusted p value) on the y axis and the fold-change in relative abundance on the×axis for all metabolites detected in the shown comparisons. Coloring labels fold-change, with blue being down-regulated and yellow being up-regulated.
