Subject area	Neuroscience, Radiology
More specific subject area	Diffusion tensor imaging and immunohistochemistry
Type of data	Table, fluorescence microscopy images, summary graphs
How data was acquired	Diffusion MRI was acquired on Bruker 11.7T NMR spectrometer. Two-photon laser microscopy images were acquired on Olympus FV-1000-MPE microscope.
Data format	Images and graphs
Experimental factors	Mice were transcardially perfused with a CLARITY liquid hydrogel, ex vivo brains were then immersed in PBS and 0.1 mM gadopentetate dimeglumine prior to DTI. During scanning, brains were immersed in Fomblin for susceptibility matching and to limit tissue dehydration.
Experimental features	TrackVis was used to create white matter regions-of-interest (ROIs) from DTI-derived FA maps. CLARITY images were analyzed using Imaris 8.0 with the Surfaces module to trace individual MBP-positive ROIs.
Data source location	Manhasset, New York, USA
Data accessibility	Data is provided in this article and is related to the research article [1].