Table 5.
Association of phospholipids levels (per 1-SD log-transformed) with the change in cognitive scores from the ARIC Brain MRI visit to the ARIC-NCS, Atherosclerosis Risk in Communities (ARIC) Study, 2004 to 2013
| Phospholipid | Delayed word recall test, Z score | Digit symbol substitution test, Z score | Word fluency test, Z-score | Global, Z score | Mini-mental state examination (MMSE) | |
|---|---|---|---|---|---|---|
| n | 219 | 204 | 218 | 202 | 191 | |
| PC aa C36:6 | β | 0.01 | −0.002 | 0.03 | 0.01 | −0.08 |
| 95% CI | −0.17 to 0.19 | −0.07 to 0.07 | −0.05 to 0.11 | −0.09 to 0.11 | −0.45 to 0.29 | |
| P value | .92 | .96 | .44 | .78 | .68 | |
| PC aa C38:0 | β | 0.05 | 0.02 | 0.03 | 0.03 | 0.01 |
| 95% CI | −0.14 to 0.23 | −0.05 to 0.09 | −0.05 to 0.11 | −0.07 to 0.13 | −0.36 to 0.38 | |
| P value | .60 | .58 | .47 | .54 | .96 | |
| PC aa C38:6 | β | 0.04 | 0.001 | 0.04 | 0.03 | −0.01 |
| 95% CI | −0.14 to 0.22 | −0.07 to 0.07 | −0.04 to 0.12 | −0.07 to 0.13 | −0.37 to 0.35 | |
| P value | .67 | .97 | .30 | .52 | .97 | |
| PC aa C40:1 | β | 0.03 | 0.02 | 0.03 | 0.03 | 0.02 |
| 95% CI | −0.16 to 0.22 | −0.06 to 0.09 | −0.06 to 0.11 | −0.07 to 0.14 | −0.39 to 0.43 | |
| P value | .75 | .63 | .54 | .54 | .92 | |
| PC aa C40:2 | β | −0.04 | −0.01 | −0.03 | −0.03 | −0.11 |
| 95% CI | −0.23 to 0.15 | −0.08 to 0.06 | −0.12 to 0.05 | −0.14 to 0.07 | −0.50 to 0.28 | |
| P value | .69 | .75 | .46 | .53 | .56 | |
| PC aa C40:6 | β | 0.01 | 0.01 | 0.05 | 0.03 | −0.03 |
| 95% CI | −0.18 to 0.19 | −0.06 to 0.08 | −0.03 to 0.13 | −0.07 to 0.13 | −0.40 to 0.34 | |
| P value | .95 | .76 | .23 | .54 | .87 | |
| PC ae C40:6 | β | 0.06 | 0.02 | 0.03 | 0.04 | −0.07 |
| 95% CI | −0.12 to 0.25 | −0.05 to 0.09 | −0.05 to 0.11 | −0.06 to 0.14 | −0.43 to 0.30 | |
| P value | .49 | .65 | .47 | .42 | .73 | |
| Lyso PC a C18:2 | β | 0.04 | −0.01 | −0.003 | 0.04 | −0.24 |
| 95% CI | −0.14 to 0.22 | −0.08 to 0.07) | −0.08 to 0.08 | −0.06 to 0.14 | −0.61 to 0.13 | |
| P value | .67 | .88 | .95 | .47 | .20 | |
| C3 | β | 0.13 | 0.02 | 0.05 | 0.11 | −0.05 |
| 95% CI | −0.06 to 0.32 | −0.06 to 0.09 | −0.03 to 0.14 | 0.01–0.22 | −0.45 to 0.35 | |
| P value | .18 | .67 | .22 | .03 | .81 |
NOTE. Model 2: adjusted for age, sex, APOE, body mass index, cholesterol medications, diabetes mellitus, drinking status, educational level, HDL cholesterol, smoking status, sports index, systolic blood pressure, total cholesterol, triglycerides, use of antihypertensive medications, and prevalent coronary heart disease, heart failure, or stroke at baseline.
Bold indicates statistical significance.