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. 2016 Dec 18;11:254–262. doi: 10.1016/j.redox.2016.12.010

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 1. — Artesunate selectively kills head and neck cancer (HNC) cells but not normal cells. (A, B) Cell viability was assessed after exposure to different concentrations of artesunate (Arts) in normal cells (HOK and HOF) and HNC cells, including cisplatin (cis)-resistant cells (HN3-cisR, HN4-cisR, and HN9-cisR) and their parental cells (HN3, HN4, and HN9). (C) Clonogenic assays of HNC cells and normal cells exposed to different concentrations of Arts were performed in triplicate. (D) Microphotographs show cis-sensitive (parental) and -resistant HNC cells after exposure to vehicle or 50 μM Arts for 72 h.