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. 2016 Dec 18;11:254–262. doi: 10.1016/j.redox.2016.12.010

Fig. 4.

Fig. 4.

Nrf2 activation contributes to the resistance of HNC ferroptosis. (A-D) Cis-sensitive HN9 cells were transfected with siRNA control (siCtr), siKeap1, or siNFE2L2. The mRNA (A), proteins (B), cell numbers (C), and cell viability (D) were measured after transfection with or without Arts. (E, F) Cellular GSH and lipid ROS levels were measured in HN3-cisR cells exposed to 25 or 50 μM Arts with or without trigonelline (Trig; 100 μM). The error bars represent the standard error from three replicates. *P<0.05 relative to control; *P<0.01 between the groups.