Table 1.
Characteristics of genome-wide association studies included in consortium-based meta-analyses of colorectal, breast, prostate, ovarian, and lung cancers
| Cancer Type/Subtype-Consortium | Cases (N) | Controls (N) | GWAS (N) | Genotyping Platform | Covariates |
|---|---|---|---|---|---|
| Colorectal- GECCO | 10,314 | 12,857 | 13 | Illumina 300/240S, 300K, 550K, 610K, 730K; Affymetrix 100K, 500K | age, sex, PCA, center, batch effecta, smokingb |
| Colorectal- CORECT | 5,100 | 4,831 | 6 | Affeymetrix Axiom | age, sex, PCA |
| Breast- DRIVE | 15,748 | 18,084 | 11 | llumina 240K/317K/370K/550K/610K/610K+Cyto12/660K/670K/1.2M; Affymetrix 5.0/6.0 | age, PCA |
| ER- negative | 4,939 | 13,128 | 8 | age, PCA | |
| Prostate- ELLIPSE | 14,160 | 12,724 | 6 | Illumina 550K/610K/2.5M/iSELECT; Affymetrix GeneChip 5.0 | age, study |
| Aggressive | 4,450 | 12,724 | 6 | age, study, PCA | |
| Ovarian- FOCI | 4,369 | 9,123 | 3 | Illumina 317K/370K/550K/610K/670K/2.5M | site, PCA, age |
| Endometrioid | 715 | 9,123 | 3 | site, PCA, age | |
| Serous | 2,556 | 9,123 | 3 | site, PCA, age | |
| Lung- TRICL | 12,160 | 16,838 | 6 | Illumina 317K/370K/550K/610K | age, sex, PCA |
| Adenocarcinoma | 3,718 | 15,871 | 6 | age, sex, PCA | |
| Squamous | 3,422 | 16,015 | 6 | age, sex, PCA | |
|
| |||||
| Total | 61,851 | 74,457 | 45 | ||
Abbreviations: CORECT- ColoRectal Transdisciplinary Study; DRIVE- Discovery, Biology, and Risk of Inherited Variants in Breast Cancer; ELLIPSE- Elucidating Loci Involved in Prostate Cancer Susceptibility; ER-estrogen receptor; FOCI- Follow-up of Ovarian Cancer Genetic Association and Interaction Studies; GWAS- genome wide association studies; N- number; PCA- principal components analysis; TRICL- Transdisciplinary Research in Cancer of the Lung.
Adjusted for batch effect only in the Association STudy Evaluating RISK for Sporadic Colorectal Cancer (ASTERISK) study
Adjusted for smoking only in the Physician’s Health Study (PHS)