Table 3.

Unconditional and conditional ASSET two-sided meta-analysis results across five cancer types

Unconditional Results						Cancer types		Conditional Results
Gene (Chr.) SNP	Combined P-value	Positively Associated		Inversely Associated				Combined P-value	Positively Associated		Inversely Associated
		OR (95% CI)	P-value	OR (95% CI)	P-value	Positively Associated	Negatively Associated		OR (95% CI)	P-value	OR (95% CI)	P-value
DCLRE1B (Chr. 1)
rs974404a	9.19e-06b	1.04 (1.01–1.07)	2.47E-02c	0.94 (0.91–0.97)	2.43E-05b	Breast, Ovarian	Prostate, Lung
rs12144215	1.50E-05b			0.90 (0.87–0.94)	2.11E-06b	Lungd	Colorectal, Breastd, Prostate	2.07E-05b	1.05 (1.004–1.11)	3.31E-02c	0.93 (0.90–0.96)	4.33E-05
TERC (Chr. 3)
rs80304993a	6.54E-15b			0.82 (0.78–0.86)	1.51E-15b		Prostate
rs62293480	1.35E-06b			0.89 (0.84–0.93)	5.97E-07b		Prostate	2.16E-13b			0.84 (0.81–0.88)	1.44E-14b
rs75316749	1.38E-06b	1.14 (1.08–1.20)	1.38E-06b			Colorectal, Breast, Ovary, Lung		1.46E-06b	1.14 (1.08–1.20)	1.46E-06b
TERT-CLPTM1L (Chr. 5)
rs37004a,e	2.27E-11b			0.84 (0.81–0.88)	1.29E-12b		Lung
rs7717443	5.37E-07b	1.10 (1.06–1.14)	2.24E-06b	0.95 (0.91–0.99)	1.31E-02c	Ovary, Lung	Colorectal, Prostate	1.26E-07b	1.11 (1.06–1.15)	5.31E-07b	0.95 (0.91–0.990)	1.19E-02c
rs10866498	6.36E-08b	1.05 (1.01–1.09)	6.76E-03	0.91 (0.88–0.94)	4.57E-07b	Colorectal, Prostate	Ovary, Lung	9.27E-18b	1.07 (1.03–1.10)	4.01E-05	0.88 (0.85–0.91)	5.25E-15b
rs12655062	1.65E-06b	1.12 (1.06–1.18)	3.53E-05	0.95 (0.92–0.98)	2.72E-03	Prostate	Colorectal, Ovarian	1.13E-06b	1.12 (1.06–1.18)	2.67E-05	0.95 (0.92–0.98)	2.42E-03
rs115960372	6.94E-07b	1.19 (1.10–1.27)	2.97E-06b	0.90 (0.83–0.98)	1.29E-02c	Prostate	Lung	3.12E-06b	1.17 (1.09–1.26)	1.20E-05b	0.91 (0.84–0.98)	1.57E-02c
rs2736098e	2.48E-07b	1.08 (1.04–1.12)	1.81E-04	0.93 (0.90–0.97)	7.16E-05	Prostate, Lung	Colorectal, Breast, Ovarian	5.36E-06b	1.08 (1.02–1.14)	1.23E-02c	0.93 (0.91–0.96)	2.74E-05
POT1 (Chr. 7)
rs116895242	5.21E-05			0.83 (0.77–0.90)	6.99E-06b		Colorectal, Ovarian, Lung
RTEL1 (Chr. 20)
rs34978822f	2.14E-05			0.71 (0.62–0.82)	3.17E-06b		Prostate, Lung

Abbreviations: Chr.- chromosome; CI- confidence interval; OR- odds ratio; SNP- single nucleotide polymorphism.

^aThe most significant SNP is always conditioned on in the sequential conditional analysis (and therefore there are no conditional results for it)

^bGene level P-value thresholds based on the number of effective tests are: DCLER1B P<2.65×10−5; TERC P<2.45×10−5; TERT-CLPTM1 P<1.32×10−5; POT1 P-value<2.94×10−5; RTEL1 P-value<1.86×10−5.

^cPositive or inverse associations with P-values between 0.01 and 0.05 are considered to be suggestive.

^dAssociations with phenotypes were statistically significant in conditional analyses only

^eSNPs that are directly measured and not imputed.

^fASSET meta-analytical results for these SNPs are based on 4 cancer types rather than all 5 studies.