Table 3.
Neurotransmitter levels in the prefrontal cortex.
| TAT-/Sel- | TAT+/Sel- | TAT-/Sel+ | TAT+/Sel+ | SME | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
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| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | Sel | TAT | |
| Dopamine system | ||||||||||
| DA | 114.67 | 5.51 | 117.04 | 7.39 | 142.23 | 10.60 | 146.42 | 18.23 | * | |
| DOPAC | 74.07 | 3.71 | 68.39 | 2.64 | 59.16 | 2.80 | 65.59 | 3.74 | ** | |
| 3-MT | 22.21 | 1.09 | 23.20 | 1.13 | 26.32 | 1.22 | 27.64 | 2.03 | ** | |
| HVA | 65.48 | 2.88 | 68.11 | 3.40 | 64.71 | 5.08 | 67.37 | 5.59 | ||
| DOPAC/DA | 0.6568 | 0.0325 | 0.6103 | 0.0338 | 0.4294 | 0.0204 | 0.4994 | 0.0437 | *** | |
| HVA/DA | 0.5857 | 0.0311 | 0.6042 | 0.0343 | 0.4609 | 0.0249 | 0.4928 | 0.0412 | *** | |
| DOPAC/HVA | 1.1434 | 0.0534 | 1.0287 | 0.0505 | 0.9539 | 0.0545 | 1.0786 | 0.1172 | ||
| Serotonin system | ||||||||||
| 5-HT | 516.53 | 22.76 | 554.75 | 20.47 | 604.34 | 23.08 | 608.98 | 20.76 | ** | |
| 5-HIAA | 151.60 | 8.59 | 175.19 | 10.18 | 160.82 | 9.26 | 172.50 | 14.21 | ||
| 5-HIAA/5-HT | 0.2999 | 0.0179 | 0.3175 | 0.0175 | 0.2666 | 0.0116 | 0.2822 | 0.0205 | ||
| Amino acids | ||||||||||
| GLU | 1702.7 | 71.0 | 1775.8 | 55.6 | 1774.2 | 32.0 | 1765.8 | 73.4 | ||
| GABA | 162.81 | 6.00 | 169.81 | 6.93 | 176.33 | 6.59 | 182.31 | 9.13 | ||
| Glutamine | 1101.1 | 88.9 | 1219.0 | 91.1 | 1121.9 | 73.1 | 1401.5 | 158.5 | ||
| GLU/GABA | 10.47 | 0.31 | 10.58 | 0.30 | 10.21 | 0.38 | 9.82 | 0.39 | ||
| Gln/GLU | 0.6451 | 0.0378 | 0.6823 | 0.0390 | 0.6300 | 0.0345 | 0.7787 | 0.0688 | ||
Sel, Selegiline; SME, significant main effects; SEM, standard error of the mean; DA, dopamine; DOPAC, dihydroxyphenylacetic acid; 3-MT, 3-methoxytyramine; HVA, homovanillic acid; 5-HT, serotonin; 5-HIAA, 5-hydroxy-indoleacetic acid; GLU, glutamate; GABA, γ-aminobutyric acid; Gln, glutamine.
*
p < 0.05,
**
p < 0.01,
***
p < 0.001.