Table 3.

Neurotransmitter levels in the prefrontal cortex.

	TAT-/Sel-		TAT+/Sel-		TAT-/Sel+		TAT+/Sel+		SME
	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM	Sel	TAT
Dopamine system
DA	114.67	5.51	117.04	7.39	142.23	10.60	146.42	18.23	*
DOPAC	74.07	3.71	68.39	2.64	59.16	2.80	65.59	3.74	**
3-MT	22.21	1.09	23.20	1.13	26.32	1.22	27.64	2.03	**
HVA	65.48	2.88	68.11	3.40	64.71	5.08	67.37	5.59
DOPAC/DA	0.6568	0.0325	0.6103	0.0338	0.4294	0.0204	0.4994	0.0437	***
HVA/DA	0.5857	0.0311	0.6042	0.0343	0.4609	0.0249	0.4928	0.0412	***
DOPAC/HVA	1.1434	0.0534	1.0287	0.0505	0.9539	0.0545	1.0786	0.1172
Serotonin system
5-HT	516.53	22.76	554.75	20.47	604.34	23.08	608.98	20.76	**
5-HIAA	151.60	8.59	175.19	10.18	160.82	9.26	172.50	14.21
5-HIAA/5-HT	0.2999	0.0179	0.3175	0.0175	0.2666	0.0116	0.2822	0.0205
Amino acids
GLU	1702.7	71.0	1775.8	55.6	1774.2	32.0	1765.8	73.4
GABA	162.81	6.00	169.81	6.93	176.33	6.59	182.31	9.13
Glutamine	1101.1	88.9	1219.0	91.1	1121.9	73.1	1401.5	158.5
GLU/GABA	10.47	0.31	10.58	0.30	10.21	0.38	9.82	0.39
Gln/GLU	0.6451	0.0378	0.6823	0.0390	0.6300	0.0345	0.7787	0.0688

Sel, Selegiline; SME, significant main effects; SEM, standard error of the mean; DA, dopamine; DOPAC, dihydroxyphenylacetic acid; 3-MT, 3-methoxytyramine; HVA, homovanillic acid; 5-HT, serotonin; 5-HIAA, 5-hydroxy-indoleacetic acid; GLU, glutamate; GABA, γ-aminobutyric acid; Gln, glutamine.

^*p < 0.05,

^**p < 0.01,

^***p < 0.001.