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. Author manuscript; available in PMC: 2017 Nov 21.
Published in final edited form as: Dev Cell. 2016 Nov 10;39(4):480–490. doi: 10.1016/j.devcel.2016.10.001

Figure 6.

Figure 6

Maturation defects in Nkx2.5+/− CMs. A) Developmental profile of E9.5 VEN and E14.5, P0, and P21 LV CMs from WT (dashed line) and Nkx2.5+/− mice (solid line) depicted using density plots as described in Fig. 4B. At E14.5 (2nd panel), Nkx2.5+/− CMs are less mature than E14.5 WT cells. This immaturity decreases gradually from P0 (3rd panel) to P21 (4th panel). B) Using hierarchical clustering, the proportion Nkx2.5+/− CMs (CM) that cluster with similarly aged WT cells is significantly different at all time points (Fisher's exact p-values: E14.5= 2.1×10−25, P0= 0.0012, P7= 0.010, P21= 0.0071). See also Fig S5 and Table S4.