Table 2.
ACT inhibition and cytotoxic effects of bisamidate prodrugs of 5-chloroanthraniloyl-substituted acyclic nucleoside phosphonates in J774A.1 cells.
| Compound | IC50[µM][a] | Viability [%][b] |
|---|---|---|
| 3 + 4 | > 15 | ND |
| 6 | > 15 | ND |
| 7 | > 15 | ND |
| 11 | > 15 | ND |
| 14 | > 15 | ND |
| 20 | > 15 | ND |
| 22 | > 15 | ND |
| 26 | 12.1 ± 1.3 | 110 |
| 29 | > 15 | ND |
[a]
Data are the mean ± SD of at least three independent experiments.
[b]
Data are the percent cell viability at a fixed prodrug concentration (10 µM) versus untreated control; ND: not determined.