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. Author manuscript; available in PMC: 2016 Dec 29.
Published in final edited form as: Organic Synth. 2016;93:75–87. doi: 10.15227/orgsyn.093.0075

Table 1.

Substrate Scope

graphic file with name nihms798827u2.jpg
entry R n catalyst time (h) temp (°C) yield (%)a ee (%)b
1 Me (5a) 1 S 120 25 95 98
2 Me (5a) 1 R (1 mol%) 48 80c 96 98
3 H (5b) 1 S 72 5 93 91
4 Et (5c) 1 S 120 25 93 95
5 i-Pr (5d) 1 R 192 35 89 90
6 allyl (5e) 1 R 168 35 96 97
7 benzyl (5f) 1 S 155 35 67 94
8 Me (5g) 2 S 144 25 84 86
a

isolated yield;

b

determined by GC or HPLC analysis with a chiral support column;

c

toluene used as solvent.