Table 2.

Shown in (a) are the estimates of the log hazard ratio (logHR) along with their corresponding standard errors (SE) and p-values by fitting stratified Cox model integrating information from 4 independent studies with imputed miRNA based on the SMC method and the nuclear norm minimization (NNM); and Cox model to the TCGA test data with original observed miRNA (Ori.). Shown also are the estimates for each individual studies by fitting separate Cox models with imputed miRNA.

(a) Integrated Analysis with Imputed miRNA vs Single study with observed miRNA
	logHR			SE			p-value
	Ori.	SMC	NNM	Ori.	SMC	NNM	Ori.	SMC	NNM
	.067	.143	.168	.041	.034	.028	.104	.000	.000
${\text{miRNA}}_1^{\text{PC}}$	−.012	−.019	−.013	.009	.006	.012	.218	.001	.283
${\text{miRNA}}_2^{\text{PC}}$	.023	.018	−.005	.014	.009	.014	.092	.039	.725

(b) Estimates for Individual Studies with Imputed miRNA from the SMC method
	logHR				SE				p-value
	TCGA	TOTH	DRES	BONO	TCGA	TOTH	DRES	BONO	TCGA	TOTH	DRES	BONO
	.051	.377	.174	.311	.048	.069	.132	.117	.286	.000	.187	.008
${\text{miRNA}}_1^{\text{PC}}$	−.014	−.021	−.031	−.010	.011	.012	.014	.014	.207	.082	.030	.484
${\text{miRNA}}_2^{\text{PC}}$	.014	.045	−.021	.036	.016	.018	.022	.019	.391	.009	.336	.054

(c) Estimates for Individual Studies with Imputed miRNA from the NNM method
	logHR				SE				p-value
	TCGA	TOTH	DRES	BONO	TCGA	TOTH	DRES	BONO	TCGA	TOTH	DRES	BONO
	.082	.405	.361	.258	.037	.066	.114	.088	.028	.000	.002	.003
${\text{miRNA}}_1^{\text{PC}}$	−.045	.016	.055	−.008	.021	.026	.031	.023	.034	.544	.076	.721
${\text{miRNA}}_2^{\text{PC}}$	.008	−.086	−.043	.019	.026	.027	.034	.029	.758	.002	.201	.496