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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Pediatr Res. 2016 Apr 13;80(2):209–217. doi: 10.1038/pr.2016.97

Table 4.

Population pharmacokinetic parameter estimates for a typical infant (fixed effects)

Parameter Units Estimates (Standard Error)
Single IV Administration Dataset Multiple IV Administration Dataset Combined Dataset
Model Parameters
V – volume l/kg 0.5115 (0.0345) 0.6572 (0.0707) 0.5610 (0.0341)
Cl – clearance (l/kg)/h 0.0679 (0.0064) 0.0577 (0.0061) 0.0616 (0.0048)
R – endogenous infusion rate (mg/kg)/h 2.666 (0.2762) 2.369 (0.3151) 2.449 (0.2336)
Standard deviation of residual error mg/l 18.71 (1.048) 24.77 (0.971) 22.96 (0.739)
Derived Values
k – elimination rate (=Cl/V) 1/h 0.1327 (0.0154) 0.0878 (0.0137) 0.1098 (0.0109)
t1/2 – half=life (=.693/k) h 5.22 (0.605) 7.90 (1.229) 6.31 (0.631)
E – concentration due to endogenous infusion (=R/Cl) mg/l 39.26 (1.655) 41.06 (1.777) 40.71 (1.255)