Table 2.
Univariate and multivariable analysis of overall survival in lung adenocarcinoma tissue microarray
| Univariate analysis |
Multivariable analysis |
|||
|---|---|---|---|---|
| Variable | HR (95% CI) | P* | HR (95% CI) | P* |
| Sex | ||||
| Female | Reference | Reference | ||
| Male | 1.73 (1.23 to 2.43) | .002 | 1.68 (1.18 to 2.40) | .004 |
| Age, y | ||||
| >65 | Reference | Reference | ||
| ≤65 | 0.97 (0.69 to 1.36) | .84 | 0.74 (0.51 to 1.07) | .11 |
| Smoking status | ||||
| Current smoker | Reference | Reference | ||
| Former smoker | 0.84 (0.58 to 1.21) | .35 | 0.77 (0.52 to 1.14) | .19 |
| Never smoker | 0.81 (0.49 to 1.34) | .41 | 0.96 (0.56 to 1.65) | .89 |
| Stage | ||||
| I | Reference | Reference | ||
| II | 2.21 (1.44 to 3.41) | <.001 | 1.97 (1.27 to 3.06) | .003 |
| III | 2.45 (1.60 to 3.75) | <.001 | 2.17 (1.39 to 3.38) | <.001 |
| IV | 2.50 (1.33 to 4.70) | .004 | 2.68 (1.42 to 5.08) | .003 |
| CPS1 immunostaining | ||||
| Negative | Reference | Reference | ||
| Positive | 2.57 (1.75 to 3.77) | <.001 | 3.03 (1.74 to 5.25) | <.001 |
| LKB1 immunostaining | ||||
| Negative | Reference | Reference | ||
| Positive | 0.62 (0.42 to 0.91) | .01 | 1.23 (0.72 to 2.11) | .44 |
*
P values were calculated by two-sided Fisher’s exact test. CI = confidence interval; HR = hazard ratio.